NAMENDA XR® Dosing Information
Dosing For Patients Currently Taking NAMENDA
NAMENDA XR capsules offer convenient once-daily dosing for your patients
- Once-daily formulation aligns with once-daily AChEI regimens1
- Can be administered day or night, with or without food2
Patients taking combination therapy with a once-daily AChEI may be able to receive all
Alzheimer's disease treatments just once a day.
No titration required for patients already taking NAMENDA® (memantine HCI)
- Patients can switch directly from the 20 mg dose (10 mg tablets twice daily) immediate-release
NAMENDA to 28 mg once-daily NAMENDA XR capsules following the last dose of a 10 mg tablet.
There is no study addressing the comparative efficacy of these 2 regimens2
Note: Actual size of pills is smaller than shown.
In patients with severe renal impairment, it is recommended that a patient who is on NAMENDA 5 mg
twice-daily tablets be switched to a NAMENDA XR 14 mg once-daily capsule following the last
dose of 5 mg NAMENDA tablets2
- NAMENDA XR may be administered day or night, with or without food2
- NAMENDA XR capsules may be opened, and the contents sprinkled on applesauce for patients who have
difficulty swallowing pills2
- Entire contents of NAMENDA XR capsules must be consumed; the dose should not be divided
Dosage and Administration
The recommended starting dose of NAMENDA XR is 7 mg once daily. The recommended target dose is 28 mg
once daily. The dose should be increased in 7 mg increments to 28 mg once daily. The minimum recommended
interval between dose increases is one week, and only if the previous dose has been well tolerated. The maximum
recommended dose is 28 mg once daily.
It is recommended that a patient who is on a regimen of 10 mg twice daily of NAMENDA tablets be switched to
NAMENDA XR 28 mg once-daily capsules the day following the last dose of a 10 mg NAMENDA tablet. There
is no study addressing the comparative efficacy of these 2 regimens.
It is recommended that a patient with severe renal impairment who is on a regimen of 5 mg twice daily of NAMENDA
tablets be switched to NAMENDA XR 14 mg once-daily capsules the day following the last dose of a 5 mg
NAMENDA XR should be administered with caution to patients with severe hepatic impairment.
A target dose of 14 mg/day is recommended in patients with severe renal impairment (creatinine clearance of
5-29 mL/min, based on the Cockcroft-Gault equation).
Learn how NAMENDA XR works in combination with an AChEI
View NAMENDA XR side effects and pharmacokinetic drug interactions
- Data on file. Forest Laboratories, LLC
NAMENDA XR (memantine HCl) extended-release Prescribing Information. Cincinnati, OH: Forest Pharmaceuticals, Inc.; 2014.